The short wavelength-sensitive (S) cones comprise less than 10% of the cone photoreceptors in the primate retina and investigation of their specialized role in color vision has a long history. Our first encounter with this distinctive pathway came with the discovery in the 1990's of a novel ganglion cell type that transmitted a 'blue-yellow' color signal to the brain. Since then we have continued to study many features of this neural circuit, including the physiology of the S-cone themselves, interneurons linked to the S-cone as well as other S-cone related color coding visual pathways. Currently we are using the connectomics approach to characterize new features of the S-cone circuitry in the human retina and calcium imaging of dendritic processing in the macaque retina to better understand how color opponency originates in this fascinating visual pathway.
See A RECENT PUBLICATION IN PNAS
Structure and function are inextricably linked in the profound complexity of the human retinal fovea. The human foveal connectome project centered in our lab is a collaborative effort designed to apply recently developed method of volume electron microscopy - connectomics - to addressing many of the outstanding questions about the structure and function of the human fovea.
Neural coding for motion direction has been studied intensively in
the visual cortex of non-human primates. Here, we establish an origin
for direction selectivity at the first step in the visual process in the retina
of the macaque monkey.